Domain

NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain (IPR019575)

Short name: Nuop51_4Fe4S-bd

Domain relationships

None.

Description

NADH:ubiquinone oxidoreductase (complex I) (EC:1.6.5.3) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [PMID: 10940377], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [PMID: 18394423].

Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 51 kDa (in mammals), which is the second largest subunit of complex I [PMID: 2029890]. The 51 kDa subunit, as the corresponding bacterial subunit (Nqo1 in Thermus and NuoF in E. coli) [PMID: 12600193], contains the NADH-binding site, the primary electron acceptor FMN-binding site, and a 4Fe-4S cluster [PMID: 16469879].

This entry represents the iron-sulphur binding domain.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0051539 4 iron, 4 sulfur cluster binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam