Domain

Involucrin, N-terminal (IPR019571)

Short name: Involucrin_N

Domain relationships

None.

Description

Involucrin [PMID: 1359382, PMID: 8277848] is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane [PMID: 8098344] functioning as a glutamyl donor during assembly of the cornified envelope.

Structurally involucrin consists of a conserved region of about 75 amino acid residues followed by two extremely variable length segments that contain glutamine-rich tandem repeats. The glutamine residues in the tandem repeats are the substrate for the tranglutaminase in the cross-linking reaction. The total size of the protein varies from 285 residues (in dog) to 835 residues (in orangutan).

This is the N-terminal three beta strands of involucrin, a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. It has been found that apigenin regulates normal human keratinocyte differentiation by suppressing it and this is associated with reduced cell proliferation without apoptosis [PMID: 16982614]. The downstream part of the protein is represented by IPR000354.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam