Domain

Rapsyn, myristoylation/linker region, N-terminal (IPR019568)

Short name: Rapsyn_myristoylation/link_N

Domain relationships

None.

Description

Neuromuscular junction formation relies upon the clustering of acetylcholine receptors and other proteins in the muscle membrane. Rapsyn is a peripheral membrane protein that is selectively concentrated at the neuromuscular junction and is essential for the formation of synaptic acetylcholine receptor aggregates. Acetylcholine receptors fail to aggregate beneath nerve terminals in mice where rapsyn has been knocked out. The N-terminal six amino acids of rapsyn are its myristoylation site, and myristoylation is necessary for the targeting of the protein to the membrane [PMID: 15730871].

GO terms

Biological Process

GO:0007268 synaptic transmission

Molecular Function

GO:0033130 acetylcholine receptor binding
GO:0008270 zinc ion binding

Cellular Component

GO:0030054 cell junction
GO:0005856 cytoskeleton
GO:0045211 postsynaptic membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam