Myelin-PO, C-terminal (IPR019566)

Short name: Myelin-PO_C

Overlapping homologous superfamilies


Domain relationships



The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction. The P0 glycoprotein, absent in the central nervous system [PMID: 2435734], is a major component of the myelin sheath in peripheral nerves. It comprises a large extracellular N-terminal domain, a single transmembrane (TM) region, and a smaller positively charged intracellular domain. It is postulated that P0 is a structural element in the formation and stabilisation of peripheral nerve myelin [PMID: 2578885], holding its characteristic coil structure together by the interaction of its positively-charged domain with acidic lipids in the cytoplasmic face of the opposed bilayer, and by interaction between hydrophobic globular `heads' of adjacent extracellular domains [PMID: 2435734].

This entry is the extracellular domain found at the C-terminal end of myelin-PO.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.