Translocon Sec61/SecY, plug domain (IPR019561)

Short name: Translocon_Sec61/SecY_plug_dom

Overlapping homologous superfamilies

Domain relationships



The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side. The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilising Sec61p during translocon formation. The domain runs from residues 52-74 [PMID: 16822836].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.