Family

Phosphatidylinositol-glycan biosynthesis class S protein (IPR019540)

Short name: PtdIno-glycan_biosynth_class_S

Family relationships

None.

Description

Phosphatidylinositol-glycan biosynthesis class S protein (PIG-S, also known as Gpi17 in budding yeasts) is one of several key, core components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that adds GPIs to newly synthesized proteins [PMID: 11598210]. Mammalian GPI transamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for its function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U [PMID: 14660601].

GO terms

Biological Process

GO:0016255 attachment of GPI anchor to protein

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0042765 GPI-anchor transamidase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER