Nuclear RNA-splicing-associated protein, SR-25 (IPR019532)

Short name: Nucl_RNA-splicing_assoc_SR-25

Overlapping homologous superfamilies


Family relationships



SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissue types. At the N terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localisation signals strongly implies that this is a nuclear protein that may contribute to RNA splicing [PMID: 10708573]. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1; also see IPR019093) signalling pathway [PMID: 17952876].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.