Intra-flagellar transport protein 57 (IPR019530)

Short name: Intra-flagellar_transport_57

Overlapping homologous superfamilies


Family relationships



Eukaryotic cilia and flagella are specialised organelles found at the periphery of cells of diverse organisms. Intra-flagellar transport (IFT) is required for the assembly and maintenance of eukaryotic cilia and flagella, and consists of the bi-directional movement of large protein particles between the base and the distal tip of the organelle. IFT particles contain multiple copies of two distinct protein complexes, A and B, which contain at least 6 and 11 protein subunits. IFT57 is part of complex B but is not, however, required for the core subunits to stay associated [PMID: 15955805]. This protein is known as Huntington-interacting protein-1 in humans.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.