Elongator complex protein 5 (IPR019519)

Short name: Elp5

Family relationships



Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The human Elongator six-subunit complex, known as holo-Elongator, has histone acetyltransferase activity directed against histone H3 and H4 [PMID: 11714725, PMID: 11904415]. It consists of two subcomplexes, a core subcomplex (ELP1-3), and an accessory subcomplex (ELP4-6) [PMID: 22556426]. Human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner [PMID: 11818576]. In yeast, the primary and probably only role of this complex is in formation of the 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) side chains on uridines at wobble position in tRNA [PMID: 15769872, PMID: 25607684].

This entry represents Elongator complex protein 5 (ELP5).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0033588 Elongator holoenzyme complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.