Elongator complex protein 5 (IPR019519)

Short name: Elp5

Overlapping homologous superfamilies


Family relationships



Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The human Elongator six-subunit complex, known as holo-Elongator, has histone acetyltransferase activity directed against histone H3 and H4 [PMID: 11714725, PMID: 11904415]. It consists of two subcomplexes, a core subcomplex (ELP1-3), and an accessory subcomplex (ELP4-6) [PMID: 22556426]. The elongator complex has been associated with many cellular activities, including transcriptional elongation [PMID: 10024884, PMID: 11689709], but its main function is tRNA modification [PMID: 15769872, PMID: 23165209]. It is required for the formation of 5-methoxy-carbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups on uridine nucleosides present at the wobble position of many tRNAs [PMID: 22889844].

This entry represents Elongator complex protein 5 (ELP5).

GO terms

Biological Process

GO:0002098 tRNA wobble uridine modification

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0033588 Elongator holoenzyme complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.