Domain

DNA endonuclease Ctp1, N-terminal (IPR019518)

Short name: CtIP_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

CtIP is predominantly a nuclear protein that complexes with both BRCA1 and the BRCA1-associated RING domain protein (BARD1). At the protein level, CtIP expression varies with cell cycle progression in a pattern identical to that of BRCA1. Thus, the steady-state levels of CtIP polypeptides, which remain low in resting cells and G1 cycling cells, increase dramatically as Dividing cells traverse the G1/S boundary. CtIP can potentially modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control [PMID: 18007598]. This N-terminal domain carries a coiled-coil region and is essential for homodimerisation of the protein [PMID: 17936710]. The C-terminal domain is family CtIP_C and carries functionally important CxxC and RHR motifs, absence of which lead cells to grow slowly and show hypersensitivity to genotoxins [PMID: 17936710].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam