Domain

Vacuolar protein sorting-associated protein 54, N-terminal (IPR019515)

Short name: VPS54_N

Domain relationships

None.

Description

This entry represents a domain found in vacuolar protein sorting-associated protein 54 (VPS54), which acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). VPS54 is required to tether the complex to the TGN. However, it is not involved in endocytic recycling [PMID: 25799061].

Proteins containing this domain also includes VPS50 (also known as Syndetin), which is a component of the EARP complex that is involved in endocytic recycling. It is required to tether the EARP complex to recycling endosomes. Nevertheless, it is involved in retrograde transport from early and late endosomes to the TGN [PMID: 25799061].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam