Domain

Protein kinase A anchor protein, nuclear localisation signal domain (IPR019510)

Short name: Kinase-A_anchor_nucl_local_sig

Domain relationships

Description

This entry represents the nuclear localisation signal-containing domain found in the cyclic AMP-dependent protein kinase A (PKA) anchor protein, AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes [PMID: 12804576]. This domain carries the nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein [PMID: 16483255].

The domain is also found in a number of other proteins, such as activating signal cointegrator 1 complex subunit 1 and leukocyte receptor cluster member 9.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam