Exosome complex component CSL4, C-terminal (IPR019495)

Short name: EXOSC1_C

Overlapping homologous superfamilies

Domain relationships



Exosome is a complex of 3' --> 5' exoribonucleases that play a major role in diverse RNA processing and degradation pathways. The eukaryotic exosome complex contains 9 proteins. Six RNase PH domain containing proteins (Rrp41, Rrp42, Rrp43, Rrp45, Rrp46, and Mtr3) form a catalytic ring, three RNA binding domain containing proteins (Rrp4,Rrp40, and Csl4) bind on top of the ring [PMID: 17174896].

This entry represents the C-terminal domain of the exosome complex component CSL4 (also known as EXOSC1). CSL4 does not have exonuclease activity, but are required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and for mRNA decay [PMID: 10465791, PMID: 17173052].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding

Cellular Component

GO:0000178 exosome (RNase complex)

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.