V(D)J recombination-activating protein 1, Zinc finger (IPR019485)

Short name: RAG1_Znf

Overlapping homologous superfamilies

Domain relationships


The development of B and T cells depends on the rearrangement of variable (V), diversity (D), and joining (J) gene segments to produce mature Ig and T cell receptor coding regions. This rearrangement process, known as V(D)J recombination is initiated by the complex, multi-domain proteins RAG1 and RAG2. The RAG proteins catalyze DNA cleavage in the first phase of the reaction using a recombination signal sequence (RSS) that flanks V, D and J segments [PMID: 9228952, PMID: 14671314, PMID: 22796426].

RAG1 contains a zinc-binding dimerization domain immediately N-terminal to the catalytic core region, which in turn contains a putative DNA-binding domain at its N terminus. The dimerization domain consists of a zinc C3HC4 RING finger and a C2H2 zinc RAG1-type finger.

The C2H2 RAG1-type zinc finger contains the hallmarks of a classical zinc finger structure with a two stranded beta-sheet and an alpha-helix [PMID: 9228952].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles