Domain

Peroxiredoxin, C-terminal (IPR019479)

Short name: Peroxiredoxin_C

Domain relationships

None.

Description

This entry represents the C-terminal domain of 1-Cys peroxiredoxin, a member of the peroxiredoxin superfamily which protect cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to corresponding alcohols [PMID: 9587003]. The C-terminal domain is crucial for providing the extra cysteine necessary for dimerisation of the whole molecule. Loss of the enzyme's peroxidase activity is associated with oxidation of the catalytic cysteine found upstream of this domain. Glutathionylation, presumably through its disruption of protein structure, facilitates access for GSH, resulting in spontaneous reduction of the mixed disulphide to the sulphydryl and consequent activation of the enzyme [PMID: 15004285]. The domain is associated with IPR000866, which carries the catalytic cysteine.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0051920 peroxiredoxin activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam