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Overview
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Structures
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Cross-references
Domain
Domain of unknown function DUF2428, death-receptor-like (IPR019442)
Short name: DUF2428_death-receptor-like
Overlapping homologous superfamilies
None.
Domain relationships
None.
Description
This domain is found in a family of proteins of unknown function that are conserved from plants to humans. Several of these proteins have been annotated as being HEAT repeat-containing proteins while others are designated as death-receptor interacting proteins, but neither of these has yet been confirmed. Aberrations in the genes encoding these proteins have been observed in benign thyroid adenomas [PMID: 12955091].
Contributing signatures
Signatures from InterPro member databases are used to construct an entry.
Pfam
- PF10350 (DUF2428)