Domain

Domain of unknown function DUF2428, death-receptor-like (IPR019442)

Short name: DUF2428_death-receptor-like

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain is found in a family of proteins of unknown function that are conserved from plants to humans. Several of these proteins have been annotated as being HEAT repeat-containing proteins while others are designated as death-receptor interacting proteins, but neither of these has yet been confirmed. Aberrations in the genes encoding these proteins have been observed in benign thyroid adenomas [PMID: 12955091].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam