Steryl acetyl hydrolase (IPR019436)

Short name: Steryl_acetyl_hydrolase

Family relationships



Sterol homeostasis in eukaryotic cells relies on the reciprocal interconversion of free sterols and steryl esters. In Saccharomyces cerevisiae (Baker's yeast) sterol acetylation requires the acetyltransferase Atf2, whereas deacetylation requires Say1, a membrane-anchored deacetylase with a putative active site in the ER lumen. Lack of Say1 results in the secretion of acetylated sterols into the culture medium, indicating that the substrate specificity of Say1 determines whether acetylated sterols are secreted from the cells or whether they are deacetylated and retained. In S. cerevisiae cells lacking Say1 or Atf2 are sensitive against the plant-derived allylbenzene eugenol and both Say1 and Atf2 affect pregnenolone toxicity, indicating that lipid acetylation acts as a detoxification pathway [PMID: 18034159].

Homologues of Say1 are present in the mammalian genome and can functionally substitute for Say1 in yeast demonstrating that part of this pathway has been evolutionarily conserved [PMID: 18034159].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.