Inclusion body clearance protein Iml2/Tetratricopeptide repeat protein 39 (IPR019412)

Short name: Iml2/TPR_39

Overlapping homologous superfamilies


Family relationships


This entry represents a family of proteins conserved from fungi to humans, including fungal Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some characterised proteins. Members of this family carry a tetratricopeptide repeat (IPR013105) at their C terminus.

In Saccharomyces cerevisiae, Iml2 and its paralogue-YKR018C are included in this entry. Iml2 localises to the cytoplasm and nucleus [PMID: 14562095], and its expression is increased in response to DNA replication stress [PMID: 22842922]. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress [PMID: 26004510].

In humans TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive [PMID: 9461476]. TTC39B has been linked to lipid metabolism [PMID: 20686565, PMID: 21738485].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.