Cytoplasmic tRNA 2-thiolation protein 2 (IPR019407)

Short name: CTU2

Family relationships



Cytoplasmic tRNA 2-thiolation protein 2 (also known as Ncs2/Tuc2 in budding yeasts) is responsible for 2-thiolation of mcm5S2U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln) [PMID: 18664566, PMID: 18391219]. Its fission yeast homologue, Ctu2 forms a complex with Ctu1 (Ncs6/Tuc1 homologue) and serves as a putative enzyme for the formation of 2-thiouridine [PMID: 19151091].

GO terms

Biological Process

GO:0034227 tRNA thio-modification
GO:0002098 tRNA wobble uridine modification

Molecular Function

GO:0000049 tRNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.