Lactonase, 7-bladed beta propeller (IPR019405)

Short name: Lactonase_7-beta_prop

Overlapping homologous superfamilies

Family relationships


6-phosphogluconolactonases (6PGL) EC:, which hydrolyses 6-phosphogluconolactone to 6-phosphogluconate is one of the enzymes in the pentose phosphate pathway. Two families of structurally dissimilar 6PGLs are known to exist: the Escherichia coli (strain K12) YbhE IPR022528 [PMID: 15576773] and the Pseudomonas aeruginosa DevB IPR005900 [PMID: 10869070] types.

This entry contains bacterial 6-phosphogluconolactonases (6PGL) YbhE-type EC: which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonizing enzyme carboxy-cis,cis-muconate cyclase EC: and muconate cycloisomerase EC:, which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures have been reported for the E. coli 6-phosphogluconolactonase and Neurospora crassa muconate cycloisomerase. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold [PMID: 11937053].

The surface antigen Lp49 from Leptospira interrogans, the causative agent of leptospirosis, contains a C-terminal beta propellor domain that is also included in this entry. The structure of the Lp49 protein has been solved, and because it is an antigen is a potential drug target [PMID: 18508281].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.