Selenoprotein T (IPR019389)

Short name: Selenoprotein_T

Overlapping homologous superfamilies


Family relationships


This entry represents selenoprotein T (SelT), which is conserved from plants to humans. SelT is localized to the endoplasmic reticulum through a hydrophobic domain. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding [PMID: 11278576, PMID: 19747065]. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. The function of SelT is unknown, although it may have a role in PACAP signaling during PC12 cell differentiation [PMID: 17034973, PMID: 18198219].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.