Family

Phosphofurin acidic cluster sorting protein 1 (IPR019381)

Short name: Phosphofurin_acidic_CS-1

Family relationships

None.

Description

PACS-1 is a cytosolic sorting protein that directs the localisation of membrane proteins in the trans-Golgi network (TGN)/endosomal system. PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs contained in the cytoplasmic domain of cargo proteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such as human immunodeficiency virus type 1 Nef [PMID: 9695949].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam