GDP-fucose protein O-fucosyltransferase (IPR019378)

Short name: GDP-Fuc_O-FucTrfase

Overlapping homologous superfamilies


Family relationships


This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and Caenorhabditis elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese [PMID: 11524432].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.