Smg8/Smg9 (IPR019354)

Short name: Smg8/Smg9

Overlapping homologous superfamilies


Family relationships


Smg8 and Smg9 are two subunits of the Smg-1 complex. They suppress Smg-1 kinase activity in the isolated Smg-1 complex, and are involved in nonsense-mediated mRNA decay (NMD) in both mammals and nematodes [PMID: 19417104]. NMD is a surveillance mechanism that detects and degrades mRNAs containing premature translation termination codons.

GO terms

Biological Process

GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.