Domain

CBF1-interacting co-repressor CIR, N-terminal domain (IPR019339)

Short name: CIR_N_dom

Domain relationships

None.

Description

This entry represents a 45 residue conserved domain that is found at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors).

CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex [PMID: 9874765]. It may also modulate splice site selection during alternative splicing of pre-mRNAs.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART