Intimal thickness related receptor, IRP (IPR019336)

Short name: Intimal_thickness-rel_rcpt

Overlapping homologous superfamilies


Domain relationships



This entry represents a novel protein with seven transmembrane alpha-helical domains, termed it ITR (intimal thickness-related receptor). The ITR sequence contains a motif common to the Rhodopsin-like GPCR (G protein-coupled receptor) superfamily. In vivo analyses of this gene revealed that expression of ITR protein increased with intimal thickening induced by cuff placement around murine femoral artery. Furthermore, ITR-knockout mice were found to be resistant to this experimental intimal thickening [PMID: 12538434].

GO terms

Biological Process

GO:0007186 G protein-coupled receptor signaling pathway
GO:0019236 response to pheromone

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.