Domain

FAM192A/Fyv6, N-terminal (IPR019331)

Short name: FAM192A/Fyv6_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the N-terminal domain of the mammalian PIP30/FAM192A protein and the fungal Fyv6 protein.

PIP30/FAM192A acts as a regulator of PA28-gamma, a nuclear activator of the 20S proteasome. PIP30 favors PA28-gamma interaction with the 20S proteasome while inhibiting its association with coilin, a central component of nuclear Cajal bodies [PMID: 29934401].

Fyv6 is involved in telomere length regulation and required for survival upon exposure to K1 killer toxin [PMID: 12663529, PMID: 16552446]. It promotes fully efficient non-homologous end-joining (NHEJ) by a mechanism activated in postdiauxic/stationary phase [PMID: 12399380].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam