NEDD4/Bsd2 (IPR019325)

Short name: NEDD4/Bsd2

Overlapping homologous superfamilies


Family relationships



Proteins in this entry include the human NEDD4 family-interacting protein 1/2 (Ndfip1 and Ndfip2) and the yeast Bsd2 metal homeostatis proteins.

Ndfip1 and Ndfip2 are endosomal membrane proteins that bind to and activate members of the Nedd4 family of E3 ubiquitin ligases [PMID: 19343052, PMID: 20534535]. Ndfip1 plays a role in regulating metal transport in human neurons [PMID: 19706893].

Bsd2 is required for the targeting of several proteins into the MVB (multivesicular body) pathway [PMID: 17429078]. It prevents metal hyperaccumulation by exerting negative control over the Smf1 and Smf2 metal transport systems [PMID: 9115231].

GO terms

Biological Process

GO:0030001 metal ion transport
GO:0007034 vacuolar transport

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.