Family

WASH complex subunit 3 (IPR019309)

Short name: WASHC3

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

The WASH (WASP and Scar homologue) complex is present at the surface of endosomes and recruits and activates the Arp2/3 complex to induce mediated actin nucleation. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting [PMID: 19922875].

The WASH complex consists of several subunits: F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 (strumpellin) and CCDC53.

This entry represents the WASH complex subunit 3, also known as CCDC53.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0071203 WASH complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam