Family

RNA transcription, translation and transport factor protein (IPR019265)

Short name: RTRAF

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This entry represents RNA transcription, translation and transport factor protein (RTRAF, also known as hCLE/C14orf166) from eukaryotes. It is part of the DDX1-HSPC117-FAM98B complex that shuttles between the nucleus and the cytoplasm transporting RNAs [PMID: 24608264]. It is also a component of the tRNA-splicing ligase complex and is required for tRNA ligation [PMID: 24870230]. Human RTRAF works as a positive modulator of the RNA polymerase II activity [PMID: 16950395]. It also interacts with influenza virus polymerase subunit PA and plays an important role in influenza virus replication [PMID: 21900157].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER