Domain

Transcription elognation factor Eaf, N-terminal (IPR019194)

Short name: Tscrpt_elong_fac_Eaf_N

Domain relationships

None.

Description

This entry represents the N-terminal domain of ELL-associated factor (Eaf) proteins, which act as transcriptional transactivators of ELL and ELL2 RNA Polymerase II (Pol II) transcriptional elongation factors [PMID: 11418481, PMID: 12686606, PMID: 16006523, PMID: 16006523]. Eaf proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. ELL and EAF1 are components of Cajal bodies, which have a role in leukemogenesis [PMID: 12686606]. EAF1 also has the capacity to interact with ELL1 and ELL2. The N terminus of approx 120 of EAF1 has a region of high serine, aspartic acid, and glutamic acid residues [PMID: 11418481, PMID: 17150956].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam