Domain

mRNA decay factor PAT1 domain (IPR019167)

Short name: PAT1_dom

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents a domain found in Pat1 and its homologues.

Pat1 is involved in translational repression and enhanced mRNA decay. It is part of the Lsm1-7-Pat1 complex that plays a role in activation of deadenylation-dependent decapping in the 5' to 3' pathway and in the protection of mRNA 3' ends [PMID: 25035297].

There are two Pat1 homologues in vertebrates, Pat1a and Pat1b, in contrast to the single protein in yeast and invertebrates. The maternally expressed Pat1a protein acts as a translational repressor, while Pat1b functions in mRNA decay in somatic cells. Pat1b is localised to P-body and is a nucleocytoplasmic shuttling protein that may perform various nuclear functions upstream of their multiple posttranscriptional regulatory roles in the cytoplasm [PMID: 22090346].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam