Nuclear protein DGCR14/ESS-2 (IPR019148)

Short name: Nuclear_protein_DGCR14_ESS-2

Overlapping homologous superfamilies


Family relationships



This entry represents a family of proteins known variously as DiGeorge syndrome critical region 14 (DGCR14), DiGeorge syndrome protein I (DGSI), ES2 and ESS-2. In yeast the homologue is known as stress response protein Bis1. Proteins in this family consist of approximately 500 residues with alternating regions of low complexity and conservation where the domain similarities are strong. They contain two predicted coiled-coil regions. ESS-2 has been shown to be involved in pre-mRNA splicing [PMID: 25194163]. Similarly DGCR14 has been shown to be a noncore component of the spliceosome C complex [PMID: 22365833].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.