Polycomb protein, VEFS-Box (IPR019135)

Short name: Polycomb_protein_VEFS-Box

Overlapping homologous superfamilies


Domain relationships



The VEFS-Box is found in the the C-terminal region of the VRN2, EMF2, FIS2, and Su(z)12 polycomb proteins. This domain is characterised by an acidic cluster and a tryptophan/methionine-rich sequence, the acidic-W/M domain [PMID: 11701882]. In some proteins the VEFS-Box is associated with a zinc-finger domain located roughly 100 residues towards the N terminus. These proteins are part of the polycomb cluster of proteins which control HOX gene transcription as it functions in heterochromatin-mediated repression [PMID: 11546753].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.