Mitochondrial inner membrane protein Mitofilin (IPR019133)

Short name: Mt-IM_prot_Mitofilin

Family relationships



Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex [PMID: 8886976]. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence (residues 1-43) rich in positive-charged and hydroxylated residues and a membrane anchor domain (residues 47-66). In addition, it has three centrally located coiled coil domains (residues 200-240,280-310 and 400-420) [PMID: 15647377].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.