Sister chromatid cohesion protein Dcc1 (IPR019128)

Short name: Dcc1

Overlapping homologous superfamilies


Family relationships



Sister chromatid cohesion protein Dcc1 is a component of the RFC-like complex Ctf18-RFC. This complex is required for the efficient establishment of chromosome cohesion during S-phase and may load or unload Pol30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighbouring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA [PMID: 11389843, PMID: 15964801].

GO terms

Biological Process

GO:0007064 mitotic sister chromatid cohesion

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031390 Ctf18 RFC-like complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.