Domain

RNA ligase T4 Rnl1, N-terminal (IPR019039)

Short name: RNA_ligase_T4-Rnl1_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the N-terminal domain of the T4 RNA ligase 1 (also known as Rnl1). Host defence to phage may include cleavage and inactivation of specific tRNA molecules; Rnl1 acts to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. Proteins containing this domain also include fungal tRNA ligases that have adenylyltransferase activity [PMID: 12933796]. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns. Please see the following relevant references: [PMID: 12466548, PMID: 1922054].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam