RNA cap guanine-N2 methyltransferase (IPR019012)

Short name: RNA_cap_Gua-N2-MeTrfase

Overlapping homologous superfamilies

Family relationships



RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe (Fission yeast) trimethylguanosine synthase (Tgs1) and Giardia lamblia (Giardia intestinalis) Tgs2, catalyse the methylation step(s) for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure [PMID: 17284461, PMID: 18840651, PMID: 15590684]. Trimethylguanosine synthase is specific for guanine, and N7 methylation must precede N2 methylation. This enzyme is required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. As such, this enzyme plays a role in transcriptional regulation.

GO terms

Biological Process

GO:0009452 7-methylguanosine RNA capping
GO:0001510 RNA methylation

Molecular Function

GO:0008168 methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.