Uncharacterised protein family FAM123 (IPR019003)

Short name: Uncharacterised_FAM123

Family relationships



This entry contains proteins that have no known function.

The entry includes the WTX protein, which is an X chromosome gene; Wilms' tumor gene on the X chromosome (WTX) [PMID: 18720004]. WTX protein is a protein encoded by a gene mutated in Wilms tumors and it forms a complex with beta-catenin, AXIN1 and beta-TrCP2 (beta-transducin repeat-containing protein 2) [PMID: 17510365]. The WTX protein is found to be inactivated in one third of Wilms' tumours [PMID: 17204608].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.