Family

APC membrane recruitment protein (IPR019003)

Short name: AMER

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This entry includes APC membrane recruitment protein 1/2/3 (Amer1/2/3). Amer1, also known as WTX, binds to the tumour suppressor adenomatous polyposis coli and acts as an inhibitor of Wnt signaling by inducing beta-catenin degradation [PMID: 21498506]. Amer2 is a negative regulator of Wnt/beta-catenin signaling involved in neuroectodermal patterning [PMID: 22128170].

WTX is a novel gene mutated in a proportion of Wilms' tumors and in patients suffering from sclerosing bone dysplasia [PMID: 20843316].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER