RNA helicase UPF1, UPF2-interacting domain (IPR018999)

Short name: RNA-helicase_UPF1_UPF2-interct

Overlapping homologous superfamilies


Domain relationships



UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD) [PMID: 16931876].

GO terms

Biological Process

GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0008270 zinc ion binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.