Man1-Src1p-C-terminal domain (IPR018996)

Short name: MSC

Overlapping homologous superfamilies


Domain relationships



MAN1 is an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organisation. The C-terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad [PMID: 16648637]. This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands [PMID: 15611647].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005639 integral component of nuclear inner membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.