U3 small nucleolar RNA-associated protein 15, C-terminal (IPR018983)

Short name: U3_snoRNA-assocProt_15_C

Overlapping homologous superfamilies


Domain relationships



This entry represents the C-terminal domain of the U3 small nucleolar RNA-associated protein 15 (UTP15). This protein is involved in nucleolar processing of pre-18S ribosomal RNA, and is required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). UTP15 is a component of the ribosomal small subunit (SSU) processome, which is a large ribonucleoprotein (RNP) required for processing of precursors to the small subunit RNA, the 18S, of the ribosome [PMID: 15590835, PMID: 15489292]. This domain is found C-terminal to the WD40 repeat (IPR001680). UTP15 associates with U3 snoRNA, which is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA [PMID: 12068309].

GO terms

Biological Process

GO:0006364 rRNA processing

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005730 nucleolus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.