RQC domain (IPR018982)

Short name: RQC_domain

Overlapping homologous superfamilies

Domain relationships



This entry represents the RQC domain, which is a DNA-binding domain found only in RecQ family enzymes. RecQ family helicases can unwind G4 DNA, and play important roles at G-rich domains of the genome, including the telomeres, rDNA, and immunoglobulin switch regions. This domain has a helix-turn-helix structure and acts as a high affinity G4 DNA binding domain [PMID: 16530788]. Binding of RecQ to Holliday junctions involves both the RQC and the HRDC domains.

GO terms

Biological Process

GO:0006281 DNA repair
GO:0006260 DNA replication

Molecular Function

GO:0043140 ATP-dependent 3'-5' DNA helicase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.