SMI1/KNR4-like domain (IPR018958)

Short name: SMI1/KNR4-like_dom

Domain relationships



This domain is found in the yeast cell wall assembly regulator SMI1 and the cell proliferation protein KNR4 [PMID: 7937796, PMID: 8289782].

Saccharomyces cerevisiae protein Smi1 has a regulatory role in chitin deposition and in cell wall assembly [PMID: 10206705].

KNR4 is believed to connect the PKC1-SLT2 MAPK pathway with cell proliferation. It has been shown to interact with BCK2, a gene involved in cell cycle progression in S. cerevisiae (forming a complex) to allow PKC1 to coordinate the cell cycle (cell proliferation) with cell wall integrity [PMID: 12185498, PMID: 12823808]. KNR4 also interacts with the tyrosine-tRNA synthetase protein encoded by TYS1 and is involved in sporulation process [PMID: 11410349].

Proteins containing this domain also include the animal F-box only protein 3 (FBXO3). In humans, FBXO3 is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex [PMID: 18809579].

Interestingly, Smi1/Knr4 homologues from bacteria are potential immunity proteins in a subset of these contact-dependent inhibitory toxin systems [PMID: 21306995].

Note: previously reported evidence that KNR4 may interact with nuclear matrix-association region [PMID: 8516310] may be due to an artefact [PMID: 10206705].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.