2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal (IPR018952)

Short name: 2-5-oligoAdlate_synth_1_dom2/C

Overlapping homologous superfamilies

Domain relationships



This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between residues 320 and 344 at the extreme C-terminal end [PMID: 14636576]. Oligoadenylate synthetases are antiviral enzymes that counteract viral attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesise 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication [PMID: 1651324]. This domain is often associated with IPR002934.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.