Family

Autophagy-related protein 27 (IPR018939)

Short name: Autophagy-rel_prot_27

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Autophagy is a degradative transport pathway that delivers cytosolic proteins to the lysosome (vacuole) [PMID: 11058089] and is induced by starvation [PMID: 9190802]. Cytosolic proteins appear inside the vacuole enclosed in autophagic vesicles. Autophagy significantly differs from other transport pathways by using double membrane layered transport intermediates, called autophagosomes [PMID: 11675007, PMID: 18472412]. The breakdown of vesicular transport intermediates is a unique feature of autophagy [PMID: 11058089]. Autophagy can also function in the elimination of invading bacteria and antigens [PMID: 18472412].

There are more than 25 AuTophaGy-related (ATG) genes that are essential for autophagy, although it is still not known how the autophagosome is made. Atg9 is a potential membrane carrier to deliver lipids that are used to form the vesicle. Atg27 is another transmembrane protein, and is a cycling protein [PMID: 17297289].

It acts as an effector of VPS34 phosphatidylinositol 3-phosphate kinase signalling and regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. It is also required for autophagy-dependent cycling of ATG9.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam