Salivary thrombin inhibitor anophelin, mosquito (IPR018932)

Short name: Thrombin_inhibitor_anophelin

Overlapping homologous superfamilies


Family relationships



Members of this family are all inhibitors of thrombin, the peptidase that is at the end of the blood coagulation cascade and which creates the clot by cleaving fibrinogen. The interaction between thrombin and fibrinogen involves two different areas of contact - via the thrombin active site and via a second substrate-binding site known as an exosite. The inhibitor acts by blocking the exosite, rather than by interacting with the active site. The inhibitors are from mosquitoes that feed on human blood and which, by inhibiting thrombin, prevent the blood from clotting and keep it flowing.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.