Conserved Site

Retro-transposon transporting motif (IPR018892)

Short name: Retro-transposon_transp_CS

Description

This is the highly conserved motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organisms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localisation signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity [PMID: 17615301].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam