Calmodulin-binding domain C0, NMDA receptor, NR1 subunit (IPR018882)

Short name: CaM-bd_C0_NMDA_rcpt_NR1

Overlapping homologous superfamilies


Domain relationships



This is a very short highly conserved domain that is C-terminal to the cytosolic transmembrane region IV of the NMDA-receptor 1. It has been shown to bind Calmodulin-Calcium with high affinity. The ionotropic N-methyl-D-aspartate receptor (NMDAR) is a major source of calcium flux into neurons in the brain and plays a critical role in learning, memory, neural development, and synaptic plasticity. Calmodulin (CaM) regulates NMDARs by binding tightly to the C0 and C1 regions of their NR1 subunit. The conserved tryptophan is considered to be the anchor residue [PMID: 18073110].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.