Cell division protein borealin (IPR018867)

Short name: Cell_div_borealin

Overlapping homologous superfamilies


Family relationships



The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Cell division cycle-associated protein 8, also known as Borealin, is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters [PMID: 15249581].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.